Pigmented Tumors of the Skin and Anoikis

České info

Pigmentové nádory kůže a anoikis

Nevocelulární nevus může vzniknout dvojí cestou:
1. po chronické solární radiaci kůže, kdy je porušena homeostáza barierových lipidů a nejen keratinocyt, ale také melanocyt je odsouzen k apoptóze. 2. Stejně může být apoptózou postižen melanocyt během fylogenetické cesty z neurální lišty do epidermis, když prochází „nepřátelským“ územím dermis. Apoptózu však může pozastavit enzymatický proces, který vede k anoikis, a ta dovede ohrožený melanocyt k nové proliferaci. Tak se vyvíjí nevocelulární nevus.

Klíčová slova:
nevocelulární nevus, anoikis, apoptóza, melanocyt.

Authors: P. Barták
Published in: Čas. Lék. čes. 2006; 145: 835-836
Category: Review Article

Overview

#Nevocellular nevus can develop by two mechanisms:
1. after the chronic solar irradiation of the skin which impairs barrier lipids’ homeostais and keratinocytes together with melanocytes undergo apoptosis; 2. Apoptosis can arise in melanocytes during phylogenetic development from the neural crest to epidermis when it migrates through the „enemy” territory of dermis. Apoptosis can be thus stopped by enzymatic process which results in anoikis and the endangered melanocyte would further proliferate. The later is the path of nevocellular nevi.

Key words:
nevocellular nevus, anoikis, apoptosis, melanocyte.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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