Wall Shear Stress an d Endothelium
Smykové napětí a endotel
Krevní tok působí na endotel třecí silou, známou jako smykové napětí. Tato lokální hemodynamická veličinavýznamně ovlivňuje genovou expresi v endotelových buňkách, a tudíž i jejich fenotyp. Důsledky působení smykovéhonapětí na endotel jsou dány jeho směrem a velikostí, ale i místní geometrií cévy a charakterem toku. Toto napětíurčuje velikost cévy a ovlivňuje její remodelaci a významně se podílí na rozvoji intimomediální hyperplazie.Výzkumse soustředí na podíl smykového napětí na aterogenezi.
Klíčová slova:
smykové napětí, endotel, ateroskleróza, hemodynamika.
Authors:
J. Rotreklová; J. Molinský; V. Tuka; J. Malík
Authors‘ workplace:
III. interní klinika 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2004; : 467-470
Category:
Overview
Blood flow influences the luminal side of vessel wall by a frictional force known as wall shear stress (WSS). Thislocal hemodynamic factor is an important determinant of endothelial gene expression and of endothelial phenotype.The effect of WSS depends on its magnitude and direction, as well as on the characteristic of vessel geometry andblood flow. WSS seems to be a critical determinant of vessel caliber, vascular remodeling and restenosis and playsa role in intimomedial hyperplasia. Research is concentrated especially on the influence of WSS on atheroscleroticplaque formation.
Key words:
wall shear stress, endothelium, atherosclerosis, hemodynamics.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
- Metamizole vs. Tramadol in Postoperative Analgesia
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- The Importance of Limosilactobacillus reuteri in Administration to Diabetics with Gingivitis
- The Importance of Hydration in Wound Healing
-
All articles in this issue
- Wall Shear Stress an d Endothelium
- Multidrug ResistanceMarkersMonitoring in AcuteMyeloid LeukemiaCells
- Comparison between Conventional Imaging Methods and PositronEmission Tomography in the Treatment of Hodgkin’s Lymphoma
- Atypical Pyoderma Gangrenosum in 92-Year-Old Patient
- Problems of Causality in MedicineThe Case of Viruses and Tumors – Part 2. Viruses and Human Malignant Tumors
- Deteriorative Effect of Marihuana in Years Long Interval
- Clinical Epidemiology – Critical Assessment of Treatment Methods
- The Doctors’Guide to the WHO Framework Convention on Tobacco Control
- An Analysis of the Sociodemographic Context of Alcohol Use in the Czech Adult Populationfrom the Health Perspective
- Prion Neuroinfections
- Present Position of the Hormonal Replacement Therapy
- Diagnostics and Differential Diagnostics of Dementia from the View of Internal Medicine –Geriatrics: Hazards of the False Positive Diagnose
- Junctions of Hepatology and Nephrology
- Journal of Czech Physicians
- Journal archive
- Current issue
- About the journal
Most read in this issue
- Wall Shear Stress an d Endothelium
- Deteriorative Effect of Marihuana in Years Long Interval
- Present Position of the Hormonal Replacement Therapy
- Prion Neuroinfections