Influence of Negative Interference of Pathological Bilirubin Levelson Assessment of Serum Creatinine Concentration
VLIV NEGATIVNÍ INTERFERENCE PATOLOGICKÝCHHLADIN BILIRUBINU NA STANOVENÍ KONCENTRACESÉROVÉHO KREATININU
Východisko.
Negativní interference bilirubinu s měřením koncentrace kreatininu je z biochemického hlediskaobecně známá. Cílem naší práce bylo zjistit, jak vysoké hladiny bilirubinu a při jakých koncentracích kreatininu mátento fenomén skutečný klinický význam.Metody a výsledky. U 200 náhodně vybraných vzorků jsme vyšetřili hladinu bilirubinu a kreatininu klasickoukinetickou Jaffé metodou a metodou, kde je vliv bilirubinu potlačen. Po rozdělení souboru na 8 podsouborů podlekoncentrací bilirubinu a kreatininu jsme zjistili, že interference se statisticky významně uplatňuje (p
Klíčová slova:
interference bilirubinu, stanovení kreatininu, kinetická Jaffé metoda.
Authors:
I. Smrčková; J. Charvát; D. Malá; J. Lácha 1
Authors‘ workplace:
Pracoviště specializovaných laboratoří, 1 Klinika nefrologie IKEM, Praha
Published in:
Čas. Lék. čes. 1999; : 406-408
Category:
Overview
Background.
Negative interference of bilirubin with assessment of creatinine concentration is generally knownfrom the biochemical aspect. The objective of the presented work was to find the bilirubin level and creatinineconcentration where this phenomenon has actually a clinical impact.Methods and Results. In 200 samples selected at random the bilirubin and creatinine levels were examined bythe classical Jaffé method and a method where the effect of bilirubin is suppressed. After dividing the group into 8sub-groups by bilirubin and creatinine concentrations it was revealed that the interference plays a statisticallysignificant role (p
Key words:
bilirubin interference, assessment of creatinine, Jaffé’s kinetic method.
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