Hypergastrinaemia without detection of gastrinoma

Czech version

Authors: Ľ. Cibičková ^1,2; J. Janková ³ ; Ľ. Víchová ⁴
Authors‘ workplace: Interní oddělení Nemocnice Hranice, a. s., Hranice, prim. MUDr. Zbyněk Jelínek ¹; Ústav patologické fyziologie Lékařské fakulty UP Olomouc, přednosta prof. MUDr. Jaroslav Veselý, CSc. ²; Ústav klinické a molekulární patologie Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Zdeněk Kolář, CSc. ³; Praktická lékařka pro dorost a dospělé Hranice ⁴
Published in: Vnitř Lék 2012; 58(4): 322-324
Category: Case Reports

Overview

We present a case-report of a woman with persisting gastric ulcers, who had elevated gastrin blood levels. First of all, a rare cause of hypergastrinaemia was excluded –⁠ a gastrinoma. It was not found despite of extensive investigation. Ulcers were repetitively biopted and transition of high grade dysplasia to adenocarcinoma was detected. Gastrin levels normalised after surgical antrectomia. Afterwards pernicious anaemia was diagnosed as the underlining cause of hypergastrinaemia.

Key words:
gastrin –⁠ gastrinoma –⁠ pernicious anaemia

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