The importance of serum iron levels in patients with chronic hepatitis B and C.
Význam železa v séru u nemocných s chronickou hepatitidou B a C
Význam železa v séru u chronické hepatitidy B a C není plně objasněn. Autoři vyšetřili hodnoty železa v séru u 473 pacientů, z toho u 74 HB s Ag pozitivních s chronickou hepatitidou B, 207 anti-HCV pozitivních s chronickou hepatitidou C, a u 192 náhodných kontrol s jinými nemocemi jater. Sérologické markery infekce HBV a HCV byly vyšetřeny metodami ELISA, 57 % pacientů s chronickou hepatitidou B a C mělo provedenu jaterní biopsii.
Výsledky:
Průměrná koncentrace železa v séru byla nejvyšší u pacientů s infekcí HCV (p
Závěr:
U pacientů s chronickou hepatitidou B a C bylo zjištěno statisticky významné zvýšení hodnot železa v séru a přestože je ještě v pásmu normálních hodnot, je to důležitý nález, protože je u obou hepatitid spojeno s významným zvýšením aktivity ALT a AST.
Klíčová slova:
železo, chronická hepatitida B, chronická hepatitida C, jaterní cirhóza.
Authors:
J. Stránský 1; K. Krátká 1; J. Stříteský 2
Authors‘ workplace:
I. interní klinika FNKV a 3. LF UK Praha
Přednosta: prof. MUDr. Jiří Horák, CSc.
1; Ústav patologie 1. LF UK Praha
Přednosta: prof. MUDr. Ctibor Povýšil, DrSc.
2
Published in:
Prakt. Lék. 2007; 87(4): 235-237
Category:
Of different specialties
Overview
The clinical importance of serum iron levels in hepatitis B and C patients is not fully known. Serum iron levels were tested in a total of 473 patients, of whom 74 were HBsAg positive, 207 anti-HCV positive, and 192 were random controls with other liver diseases. Serological markers of HBV and HCV infection were tested by ELISA methods, and a liver biopsy was performed in 57 % of hepatitis B and C patients.
Results:
Mean serum iron concentrations were highest in the HCV infected patients (p
Conclusions:
Significantly higher serum iron levels were detected in patients with chronic hepatitis B and C, and although they were below the upper limit of what is considered a normal value, it was an important finding because they were accompanied by significantly higher ALT and AST activity in both groups of hepatitis patients.
Key words:
iron, chronic hepatitis B, chronic hepatitis C, liver cirrhosis.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2007 Issue 4
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