Atopic dermatitis – also a psychoneurological problem
Atopická dermatitida – problém také psychoneurologický
Psychosomatická dermatologie je nezbytným následkem pozoruhodných objevů na molekulární úrovni, které původní představy Hippokratovy a Laufbergerovy převádějí do chemických vzorců. Tak vzniká nutnost, aby každá diagnóza byla založena na podkladě holistické úvahy, to předpokládá podstatné rozšíření vědomostí a současně i sjednocení pojmů všech oborů. Jedním z příkladů takové holistické úvahy a zároveň také psychosomatické poruchy je atopická diatéza, ve které dominuje porucha antigenprezentační funkce dendritických buněk všeho druhu a současně i hluboká porucha homeostázy epidermální bariéry. Závislosti těchto poruch na neuropeptidech a ostatních signálních molekulách je popsána s ohledem na neurotransmitery objevené teprve nedávno.
Klíčová slova:
atopická dermatitida – homeostáza – neuropeptidy – neurotransmitery.
Authors:
P. Barták
Authors‘ workplace:
Evropské dermatologické forum
Published in:
Prakt. Lék. 2005; 85(1): 10-12
Category:
Various Specialization
Overview
Psychosomatic dermatology is an essential consequence of remarkable discoveries at the molecular level, which transpose the original ideas of Hippocrates and Laufberger into chemical formulas. Thus, there arrises the necessity that each diagnosis be made on the basis of a holistic consideration, and that requires a substantial broadening of knowledge and at the same time also a conceptual unification in all disciplines. An example of such a holistic consideration and also of a psychosomatic disorder, is the atopic diathesis in which there is predominant a disorder in the antigen presenting function of dendritic cells of all sort, as well as a profound disorder of homeostasis in the epidermal barrier. The connection of these disorders with neurotransmitters discovered only recently.
Key words:
atopic dermatitis – homeostasis – neuropepties – neurotransmitters.
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General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2005 Issue 1
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