New Aspects in the Field of MALT Lymphomas of the Stomach
Nové pohledy na problematikuMALT lymfomu žaludku
Poznatky o MALT lymfomech žaludku z posledních let umožňují lépe pochopit jejich genezia nabízí i účinné prostředky k moderní diagnostice. Článek v krátkém přehledu shrnuje tytopoznatky s klinickou a morfologickou charakteristikou tak, aby byl zřejmý výstup v praktickédiagnostice. Zvláštní důraz je kladen na charakteristickou translokaci t(11;18) se vznikemfúzního proteinu API2-MALT1 s antiapoptotickým účinkem.
Klíčová slova:
MALT lymfom – BCL10 – API2 – MALT1 – IgH.
Authors:
J. Soukup
; L. Krsková; V. Campr
Authors‘ workplace:
Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha
Published in:
Prakt. Lék. 2004; (10): 120-125
Category:
Overview
The knowledge about MALT lymphomas has dramatically changed in the last few years. Thegenesis of MALT lymphomas has become clearer, and new tools in modern diagnostics areavailable. This article, as a concise review, summarises the latest data and the clinical andmorphological characteristics with the aspect of routine diagnostics. The characteristic translocationt(11;18) and its chimeric transcript API2-MALT1 with antiapoptotic function isemphasised.
Key words:
MALT lymphoma – BCL10 – API2 – MALT1 – IgH.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2004 Issue 10
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