Subcutaneous infliximab CT-P13 as second-line treatment after failure of anti-TNF therapy in patients with Crohn’s disease

Czech version

Authors: M. Kolář ¹ ; M. Lukáš ¹ ; D. Ďuricová ¹ ; K. Vlková ¹ ; A. Gojdičová ² ; T. Hlavatý ² ; Karin Černá ³
Authors‘ workplace: Klinické a výzkumné centrum pro idiopatické střevní záněty ISCARE a. s. a 1. LF UK, Praha ¹; Gastroenterologické centrum Bezručova, Bratislava ²; Alergologie a klinická imunologie, Gennet, Praha ³
Published in: Gastroent Hepatol 2026; 80(1): 30-35
Category: IDB: Original Article
doi: https://doi.org/10.48095/ccgh202630

Overview

This pilot, prospective, observational two-center study evaluated the efficacy and safety of subcutaneous infliximab CT-P13 S.C. as a second-line treatment in patients with moderate-to-severe Crohn’s disease who had experienced treatment failure with previous intravenous infliximab or adalimumab therapy. Sustained therapeutic response after switching administration methods was observed in 70% of patients, while plasma infliximab concentrations during subcutaneous administration reached more than three-fold higher levels compared with baseline. Half of the patients who exhibited signs of disease activity at the time of treatment transition achieved complete clinical remission. Treatment was discontinued prematurely in 30% of patients due to lack of efficacy or adverse events.

Keywords:

biological therapy – Crohn‘s disease – infl iximab CT-P13 S.C.

Sources

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Doručeno/Submitted: 9. 2. 2026

Přijato/Accepted: 13. 2. 2026

Korespondenční autor

prof. MUDr. Milan Lukáš, CSc., AGAF

Klinické a výzkumné centrum pro střevní záněty

ISCARE a. s. a 1. LF UK, Praha

Českomoravská 19

190 00 Praha 9

milan.lukas@email.cz