Ustekinumab – a new biologic drug for the treatment of Crohn’s disease
																	
									Authors:
											M. Lukáš							
								
							
																
				
									Authors‘ workplace:
											Klinické a výzkumné centrum pro střevní záněty ISCARE I. V. F. a.  s., Praha
																
				
									Published in:
					Gastroent Hepatol 2017; 71(1): 36-39
					
				
									Category:
					
					
				
									doi:
					
						https://doi.org/10.14735/amgh201736
					
							
Sources
1. Feagan BG, Sandborn WJ, Gasink C et al. Ustekinumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med 2016; 375(20): 1946 – 1960.
2. Sandborn WJ, Feagan BG, Fedorak RN et al. A randomized trial of ustekinumab a human interleukin 12/ 23 monoclonal antibody in patients with moderate to severe Crohn’s disease. Gastroenterology 2008; 135(4): 1130 – 1141. doi: 10.1053/ j.gastro.2008.07.014.
3. Sandborn WJ, Gasink C, Gao LL et al. Ustekinumab induction and maintenance therapy in refractory Crohn’s disease. N Engl J Med 2012; 367(16): 1519 – 1528. doi: 10.1056/ NEJMoa1203572.
4. Battat R, Kopylov U, Bessissow T et al. Association of ustekinumab trough concentration with clinical, biochemical and endoscopic outcome. Presented at: 11th Congress of ECCO, Amsterdam 2016.
5. Verstockt B, Van Assche G, Vermiere Set al. Biological therapy targeting the IL-23/ IL-17 axis in inflammatory bowel disease. Expert Opin Biol Ther 2017; 17(1): 31 – 47.
6. Deepak P, Loftus EV Jr. Ustekinumab in treatment of Crohn’s disease: design, development, and potential place in therapy. Drug Des Devel Ther 2016; 10 : 3685 – 3698.
7. Rutgeerts P, Gasink C, Blank M et al. A multicenter, double-blind, placebo--controlled phase 3 study of ustekinumab, a human IL-12/ 23p40 monoclonal antibody, in moderate-severe Crohn’s disease refractory to anti-TNFα: UNITI-1. Presented at: 11th Congress of ECCO, Amsterdam 2016.
8. Feagan B, Gasink C, Lang Y et al. A multicenter, randomized, double-blind, placebo-controlled phase 3 study of ustekinumab, a human monoclonal antibody to IL-12/ 23p40, in patients with moderately to severely active Crohn’s disease who are naive or not refractory to anti-TNFα: results from the UNITI-2 study. Presented at: ACG 2015.
9. Sandborn W, Feagan BG, Gasink C et al. A phase 3 randomized, multicenter, double-blind, placebo-controlled study of ustekinumab maintenance therapy in moderate – severe Crohn’s disease patients: results from IM-UNITI. Gastroenterology 2016; 150 (4 Suppl 1): S157 – S158. Abstract 768.
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Paediatric gastroenterology Gastroenterology and hepatology SurgeryArticle was published in
Gastroenterology and Hepatology
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