#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Journals / Epidemiology, Microbiology, Immunology / 2025 - 4

Detection of Panton-Valentine leukocidin-positive strains of Staphylococcus aureus from pneumonia patients in the Czech Republic in 2022–2024

Czech version

Authors: J. Bílý 1 ;  K. Mašková 1;  J. Kudláčková 2 ;  J. Závora 2 ;  P. Petráš 1
Authors‘ workplace: Národní referenční laboratoř pro stafylokoky Centra epidemiologie a mikrobiologie Státního zdravotního ústavu v Praze 1;  Klinická mikrobiologie a ATB centrum Všeobecné fakultní nemocnice v Praze 2
Published in: Epidemiol. Mikrobiol. Imunol. 74, 2025, č. 4, s. 224-229
Category:
doi: https://doi.org/10.61568/emi/11-6600/20251001/141815

Overview

Toxigenic strains of Staphylococcus aureus producing Panton-Valentine leukocidin (PVL) can cause life-threatening pneumonia in addition to skin and soft tissue infections. Pneumonia usually follows as a secondary bacterial infection after a respiratory virus infection. Between 2022 and 2024, the National Reference Laboratory for Staphylococci at the Centre for Epidemiology and Microbiology of the National Institute of Public Health in Prague confirmed PVL production in S. aureus isolates from 13 patients with invasive abscessing pneumonia. All of these patients deteriorated dramatically, needing critical care support. Nine of them died after a fulminant progression of the disease.

Keywords:

Staphylococcus aureus – Panton-Valentine leukocidin – abscessing pneumonia

Sources
  1. Hussain K, Bandyopadhyay A, Roberts N, et al. Panton-Valentine leucocidin –⁠ producing Staphylococcus aureus: a clinical review. Clin Exp Dermatol., 2022;47(12):2150–2158. PMID: 36040400. DOI: 10.1111/ced.15392.
  2. Shallcross LJ, Williams K, Hopkins S, et al. Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England. Clin Microbiol Infect., 2010;16 : 1644–1648. PMID: 20969671. DOI:10.1111/j.1469-

0691.2010.03153.x.

  1. Gillet Z, et al. Association between S. aureus strains carrying gene for Panton-Valentine leucocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lan­ cet, 2002;359 : 753–759. PMID: 11888586. DOI: 10.1016/S0140-

6736(02)07877-7.

  1. Van De Velde H. Etude sur le mécanisme de la virulence du Sta­ phylocoque pyogene. Cellule. 1894;10 : 401–410.
  2. Panton PN, Valentine FCO. Staphylococcal toxin. Lancet,

1932;219(5662):506–508.

  1. Alonzo F, Torres VJ. The bicomponent pore-forming leucodicins of S. aureus. Microb Molecular Bio Rev., 2014;78 : 99–230. PMID: 24847020. PMCID: PMC4054254. DOI: 10.1128/MMBR.00055-13.
  2. Alawad MJ, Yara S, Elgohari A, et al. Catastrophic complications of PVL-MRSA necrotizing pneumonia presenting as respiratory failure and rhabdomyolysis, case report and review of the literature. Clin Case Rep., 2022;10:e6809. PMID: 37207082. PMCID: PMC10188897. DOI: 10.1002/ccr3.6809.
  3. daSilva RS, Duarte PC, Danelli T, et al. High prevalence of Panton-Valentine leukocidin genes in MRSA isolated from inpatients with invasive infections at a University hospital in Southern Brazil. Infect Disord Drug Targets, 2023;23(3):e230822207951. PMID: 36125822. DOI: 10.2174/1871526522666220823164600.

  1. Zhu Z, Hu Z, Li S, Fang R, et al. Molecular characteristics and pathogenicity of S. aureus exotoxins. Int J Mol Sci., 2024;25 : 395. PMID: 38203566. PMCID: PMC10778951. DOI: 10.3390/

ijms25010395.

  1. Petráš P, Rumlerová M, Machová I, et al. Letální abscedující pneumonie vyvolaná kmenem S. aureus oxacilin rezistentním s produkcí PVL. Prakt lékař, 2007;88(4):236–239.
  2. Ambrožová H, Marešová V, Fajt M, et al. The first case of fatal pneumonia caused by PVL-producing S. aureus in a infant in the Czech Republic. Folia Microbiol., 2013;58 : 225–228. PMID: 23073691. DOI: 10.1007/s12223-012-0200-z.
  3. Rájová J, Pantůček R, Petráš P, et al. Necrotizing pneumonia due to clonally diverse S. aureus strains producing Panton-Valentine leucocidin: the Czech experience. Epidemiol Infect., 2016;144 : 507–515. PMID: 26201459. DOI: 10.1017/ S0950268815001521.
  4. Beneš J, Myslivec O, Laštíková J, et al. Septický šok při fatálně probíhající stafylokokové pneumonii: význam Pantonova-

-Valentinova leukocidinu –⁠ kazuistika. Anest Intenziv Med.,

2010;10(6):337–341.

  1. Petráš P, Hutníková R, Kekláková J, et al. Případy PVL pneumonie registrované v NRL pro stafylokoky CEM SZÚ 2015–2021; Zprávy CEM (SZÚ, Praha). 2021,30(11):374–376.
  2. Bílý J, Mašková K, Petráš P. Neobvyklý záchyt kmene S. condi­ menti z klinického materiálu a detekce hyaluronidázy v NRL pro stafylokoky. Zprávy CEM (SZÚ, Praha). 2024;33(9):314–317.
  3. Lina G, Piemont Y, Godail-Gamot F, et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Inf Diseases, 1999;29 : 1128–1132. PMID: 10524952. DOI: 10.1086/313461.
  4. Duployey C, Guern RL, Tines C, et al. Panton-Valentine leukocidin-secreting Staphylococcus aureus pneumonia complicating COVID-19. Emerg Infect Dis., 2020;26(8):1939–1941. PMID: 32298228. PMCID: PMC7392470. DOI: 10.3201/eid2608.201413.
  5. Morgan MS. Diagnosis nad treatment of Panton-Valentine (PVL) leucocidin –⁠ associated staphylococcal pneumonia. Int J Antimicrob Agents. 2007;30 : 289–296. PMID: 17629464. DOI:

10.1016/j.ijantimicag.2007.04.019.

  1. Shiiba R, Sano M, Kogure Y, et al. A case of community-acquired Panton-Valentine leukocidin-pozitive MRSA necrotizing pneumonia successfully treated with two anti-MRSA drugs. Re­ spir Med Case Rep., 2024; 49:e102023. PMID: 38681212. PMCID: PMC11046217. DOI: 10.1016/j.rmcr.2024.102023.
  2. Beneš J., soukromé sdělení 2025.

Poděkování

Velký dík patří NRL pro antibiotika CEM SZÚ za vyšetření PVL pozitivních kmenů S. aureus na citlivost k antibiotikům. Autoři děkují všem kolegům z 11 Oddělení klinické mikrobiologie nemocnic za zaslání informací k jednotlivým případům. Oběma recenzentům děkujeme za velice podnětné připomínky.

Do redakce došlo dne 20. 2. 2025.

Adresa pro korespondenci:

RNDr. Petr Petráš, CSc.

SZÚ Praha Šrobárova 49/48 100 00 Praha 10

e­mail: petr.petras@szu.gov.cz

Labels
Hygiene and epidemiology Medical virology Clinical microbiology
Whole genome sequencing analysis of Streptococcus pneumoniae populations of serotypes 10A, 11A, 12F, 15B, and 33F involved in invasive pneumococcal disease in the Czech Republic in 2013–2023
Microbiological findings and antimicrobial resistance dynamics in pathogens isolated from patients with toxic epidermal necrolysis: a single center experience
Still a neglected tropical disease. Epidemiological analysis of leishmaniasis in the Czech Republic in 1997–2024
Pokyny pro autory a recenzenty
Rejstřík
Article was published in

Epidemiology, Microbiology, Immunology

Issue 4
2025 Issue 4
Download issue PDF
Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#