Invasive Streptococcus pyogenes in children – a case series
Authors:
Veronika Slašťanová 1; Barbora Piteková 1,2; Jakub Gécz 1
Authors‘ workplace:
Klinika pediatrickej urgentnej medicíny, Lekárska fakulta, Univerzita Komenského, Národný ústav detských chorôb, Bratislava, Slovensko
1; Klinika pre deti a dorast A. Getlíka, Lekárska fakulta, Slovenská zdravotnícka univerzita a Univerzitná nemocnica Bratislava, Slovensko
2
Published in:
Čes-slov Pediat 2026; 81 (4): 205-208.
Category:
Case Report
doi:
https://doi.org/10.55095/CSPediatrie2026/014
Overview
Invasive Streptococcus pyogenes infections continue to pose a clinical challenge in pediatrics due to their high morbidity and mortality. The risk of a severe course of infection is higher in young children, immunocompromised patients, and in children with a concurrent viral respiratory tract infection. In our article, we discuss a series of case reports of pediatric patients with invasive streptococcal infection. Rapid diagnosis, timely initiation of antibiotic therapy, and intensive supportive care play a key role in the management of children with Streptococcus pyogenes infection.
Keywords:
Pediatrics – septic shock – Streptococcus pyogenes – invasive streptococcus
Sources
1. Walker MJ, Barnett TC, McArthur JD, et al. Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clin Microbiol Rev 2014; 27(2): 264–301.
2. Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis 2005; 5(11): 685–94.
3. O‘Loughlin RE, Roberson A, Cieslak PR, et al. The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000–2004. Clin Infect Dis 2007; 45(7): 853–62.
4. European Centre for Disease Prevention and Control. Increase in invasive group A streptococcal infections among children in Europe, 2022. ECDC Rapid Risk Assessment.
5. Daneman N, McGeer A, Green KA, et al. Epidemiology of invasive group A streptococcal infections in Ontario, Canada, 1992–2011. Clin Infect Dis 2013; 57(4): 481–89.
6. Hazelhorst EI, Ewijk CE, Wielders CCH, et al. Risk factors for invasive group A streptococcal infection in children aged 6 months to 5 years: a case-control study, the Netherlands, February–May 2023. Epidemiol Infect 2025; 153: e57.
7. Nygaard U, Hartling UB, Munkstrup C, et al. Invasive group A streptococcal infections in children and adolescents in Denmark during 2022–23 compared with 2016–17 to 2021–22: a nationwide, multicenter, population-based cohort study. Lancet Child Adolesc Health 2024; 8(2): 112–21.
8. Vieira A, Wan Y, Ryan Y, et al. Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes. Nat Commun 2024; 15(1): 3916.
9. Luca-Harari B, Darenberg J, Neal S, et al. Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol 2009; 47(4): 1155–65.
10. Ralph AP, Carapetis JR. Group A streptococcal diseases and their global burden. Curr Top Microbiol Immunol 2013; 368 : 1–27.
11. Brouwe S, Rivera-Hernandez T, Curren BF, et al. Pathogenesis, epidemiology and control of group A Streptococcus infection. Nat Rev Microbiol 2023; 21(7): 431–47.
12. Bryant AE, Stevens DL. Streptococcus pyogenes infections. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett‘s Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020.
13. Kaul R, McGeer A, Low DE, et al.; Canadian Streptococcal Study Group. Population-based surveillance for group A streptococcal necrotizing fasciitis: clinical features, prognostic indicators, and microbiologic analysis of seventy-seven cases. Am J Med 1997; 103(1): 18–24.
14. Shulman ST, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis 2012; 55(10): e86–e102.
15. De Luca M, Tripiciano C, D’Amore C, et al. Current clinical practice on the management of invasive Streptococcus pyogenes infections in children: a survey-based study. Antibiotics (Basel) 2025; 14(10): 970.
16. Garancini N, Ricci G, Ghezzi M, et al. Invasive group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center. Ital J Pediatr 2023; 49(1): 88.
17. Wong CJ, Stevens DL. Serious group A streptococcal infections. Med Clin North Am 2013; 97(4): 721–36.
18. Linnér A, Darenberg J, Sjölin J, et al. Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. Clin Infect Dis 2014; 59(3): 386–92.
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2026 Issue 4
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