Immunological and Non-immunological Factors of Progression of Nephropathies in Children
Imunologické a neimunologické faktory progresie nefropatií u detí
Glomerulonefritídy (GN)sú najčastejšou získanou progresívnou nefropatiou v detskom veku.Rýchlosť prog-resie do renálnej insuficiencie závisí okrem intenzity imunitných mechanizmov aj od genetických a metabolickýchfaktorov.Autori vyšetrili u detí s chronickými GNTH1/TH2 cytokíny,renálnu exkreciu MCP-1,TGF-beta a PDGF.S výškou kreatinémie korelovali TH1 cytokíny (p
Klíčová slova:
glomerulonefritídy u detí,imunitné mechanizmy,genetické a metabolické faktory
Authors:
Ľ. Podracká 1; M. Šašinka 1; K. Šebeková 2; J. Šalagovič 4; T. Baltesová 1; A. Böör 3; H. Hrbková 5; A. Elbertová 6
Authors‘ workplace:
Klinika detí a dorastu LF UPJŠ, Košice, 1 prednostka prof. MUDr. Ľ. Podracká, CSc. Ústav klinickej a preventívnej medicíny, Bratislava, 2 prednosta prof. MUDr. R. Dzúrik, DrSc. Ústav patologickej anatómie LF UPJŠ, Košice, 3 prednosta prof. MUDr. A. Böör,
Published in:
Čes-slov Pediat 2002; (6): 284-289.
Category:
Overview
Glomerulonephritis (GN)is the most frequent acquired progressive nephropathy of child age.The rate ofprogression up to renal insufficiency depends in addition to the intensity of immune mechanisms also on geneticand metabolic factors.The authors examined in children with chronic GN TH1/TH2 cytokines,renal excretionMCP-1,TGF-beta and PDGF.With the level of creatinaemia TH1 cytokines correlated (p
Key words:
glomerulonephritis in children,immune mechanisms,genetic and metabolic factors
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2002 Issue 6
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