Inflammatory Scar in Patients with Psoriasis
Authors:
J. Krejsek 1; J. Čelakovská 2
Authors‘ workplace:
Ústav klinické imunologie a alergologie, LF UK a FN Hradec Králové, přednosta prof. RNDr. Ctirad Andrýs, Ph. D.
1; Klinika nemocí kožních a pohlavních, LF UK a FN Hradec Králové, přednostka doc. MUDr. Jarmila Čelakovská, Ph. D.
2
Published in:
Čes-slov Derm, 100, 2025, No. 2, p. 67-74
Category:
Reviews (Continuing Medical Education)
Overview
Psoriasis is a systemic inflammatory disease with clinical presentation on skin. Pathophysiology of psoriasis is complex with genetic predisposition and substantial contribution of variable factors of both internal and external origins which is mediated by epigenetic mechanisms. Immunopathological mechanisms are the target of the most effective therapeutical modalities with the ultimate goal „clean skin“. However, the therapeutical efficacy is lost in time in majority of patients. Exacerbation of skin presentation could be caused by so called „inflammatory scar“ characterized by abnormal setting of both innate and specific immunity cellular substrate together with participation of skin cells. Inflammatory scar initiation and duration is regulated largely by epigenetic mechanisms, which could be therapeuticaly modulated in near future.
Keywords:
Psoriasis – harm inflammation – inflammatory scar
Sources
- ANTONATOS, CH., KOSKERIDIS, F., RALLIOU, CH. M. et al. A polygenic risk score model for psoriasis based on the protein interactions of psoriasis susceptibility loci. Front Genet, 2024, 15, p. 145–679.
- DACCACHE, J. A., NAIK, S. Inflammatory memory in chronic skin disease. JID Innovations, 2024, 4, p. 100–277.
- DASCALU, R. C., BARBULESCU, A. L., STOICA, L. E. et al. Review: A contemporary, multifaced insight into psoriasis pathogenesis. J Pers Med, 2024, 14, p. 535.
- FRANCIS, L., CAPON, F., SMITH, CH. et al. Inflammatory memory in psoriasis: From remission to recurrence. J Allergy Clin Immunol, 2024, 154, p. 42–50.
- FUCHS, O. Nukleofosmin s aktivitou stimulující proliferaci nebo naopak potlačující růst nádoru. Klinická onkologie, 2007, 20(6), s. 390–398.
- GU, X., NYLANDER, E., COATES, P. J. et al. Correlation between reversal of DNA methylation and clinical symptoms in psoriatic epidermis following narrow- band UVB phototherapy. J Investig Dermatol, 2015, 135, p. 2077–2083.
- HAO, Y., ZHU, Y., ZOU, S. et al. Metabolic syndrome and psoriasis: mechanisms and future directions. Front Immunol, 2021, 12, p. 71–106.
- HUANG, L., GAO, R., YU, N. et al. Dysbiosis of gut microbiota was closely associated with psoriasis. Sci China Life Sci, 2019, 62(6), p. 807–815.
- JIANG, X. et al. The role of microRNA in psoriasis: A review. Exp Dermatol, 2023, 32(10), p. 1598–1612.
- KIM, J., HE, Y., TORMEN, S. et al. The p300/CBP inhibitor A485 normalizes psoriatic fibroblast gene expression in vitro and reduces psoriasis-like skin inflammation in vivo. J Invest Dermatol, 2023, 143, p. 431–43.e19.
- KREJSEK, J., ANDRÝS, C., KRČMOVÁ, I. Imunologie člověka. 1. vyd. Hradec Králové: Garamon, 2016. 495 s. ISBN: 978-80-86472-74-4.
- LAHA, S., DAS, S., BANERJEE, U. et al. Genome-wide RNA-seq, DNA methylation and small RNA-seq analysis unraveled complex gene regulatory networks in psoriasis pathogenesis. Gene, 2025, 933, p. 148903.
- LI, H., YAO, Q., MARISCAL, A. G. et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun, 2018, 9, p. 1420.
- LIU, S., HE, M., JIANG, J. et al. Triggers for the onset and recurrence of psoriasis: a review and update. Cell Communication Signaling, 2024, 22, p. 108.
- MARTINI, E., WIKEN, M., CHEUK, S. et al. Dynamic changes in resident and infiltrating epidermal dendritic cells in active and resolved psoriasis. J Invest Dermatol, 2017, 137(4), p. 865–873.
- NETEA, M. G., JOOSTEN, L. A. B. Trained innate immunity: Concept, nomenclature, and future perspectives. J Allergy Clin Immunol, 2024, 154, p. 1079–1084.
Labels
Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2025 Issue 2
Most read in this issue
- Coincidence of Psoriasis and Atopic Dermatitis. Case Report and Literature Review
- Pemphigus vulgaris Treated with Rituximab and Intravenous Immunoglobulins
- Zápis ze schůze výboru ČDS konané dne 4. 2. 2025
- Inflammatory Scar in Patients with Psoriasis