Diurnal variation of prolactin secretion inrheumatoid arthritis patients
Diurnálny rytmus sekrécie prolaktínu u pacientov s reumatoidnou artritídou
Etiopatogenéza reumatoidnej artritídy (RA) napriek intenzívnemu úsiliu nebola zatiaľ jednoznačne objasnená. Zistenie, že prolaktín (PRL) ovplyvňuje imunitný systém podnietil vznik úvah, že môže zasahovať do etiopatogenézy reumatoidnej artritídy. Väčšina autorov zistila zvýšené hladiny PRL u pacientov s RA. Cieľom práce bolo vyšetriť diurnálnu sekréciu prolaktínu u pacientov s včasnou formou RA. Súbor a metódy. Vyšetrili sme 10 pacientov, počet žien: 8, priemerný vek: 45,5 rokov, počet mužov: 2, priemerný vek 34,7 rokov. Dĺžka trvania ochorenia: 2,07 mesiaca. Ako kontrolu sme vyšetrili sekréciu bazálneho PRL u 6 dobrovoľníkov-žien, priemerný vek 41,3 rokov. Odber sme realizovali každé 4 hodiny. Hladiny PRL sme stanovovali chemiluminiscenčnou metódou - imuno-chemická reakcia s monoklonálnou protilátkou na prístroji Imunolite. Výsledky. Hodnoty PRL u pacientov s RA boli vyššie ako u kontrolnej skupiny. Hodnoty PRL u sledovanej skupiny pacientov: o 8,00 hod.: 9,52 ng/ml, o 12,00 : 9,71 ng/ml, o 16,00 : 12,21 ng/ml, o 20,00 : 14,11 ng/ml, o 24,00 : 18,95 ng/ml, o 4,00 : 18,24 ng/ml. Štatisticky významný rozdiel medzi kontrolnou skupinou a RA sme našli o 16,00 (p
Klíčová slova:
reumatoidná artritída, prolaktín, diurnálny rytmus
Authors:
Ž. Macejová 1; D. Trejbal; I. Lazúrová
Authors‘ workplace:
I. interná klinika, LF UPJŠ a FNsP, tr. SNP 1, Košice 2IV. Interná klinika, LF UPJŠ a FNLP, Košice
1
Published in:
Čes. Revmatol., , 2004, No. 3, p. 120-124.
Category:
Overview
Despite of intensive efforts, ethiopathogenesis of rheumatoid arthritis (RA) has not been definitely solved yet. Prolactin (PRL) has been found to affect immunological system which lead to speculation about its role in ethiopathogenesis of RA. The increased levels of PRL were found in RA patients in a majority of cases. The aim of this study was to investigate diurnal secretion of prolactin in patients with early onset of RA. Patients and methods. Ten patients were evaluated, 8 women with average age of 45.5 years and 2 men with average age of 34.7 years. Duration of the disease: 2.07 months. As controls we evaluated 6 volunteers, women with average age of 41.3 years. Blood was collected at 4 hours intervals. PRL was analysed by chemiluminiscence - immunochemical reaction with mono-clonal antibody using Imunolite. Results. Compared to the control group, higher levels of PRL were found in RA patients. Mean levels of PRL in the group of RA patients: at 8.00 a.m.: 9.52 ng/ml, at 12.00 p.m.: 9.71 ng/ml, at 4.00 p.m.: 12.21 ng/ml, at 8.00 p.m.: 14.11 ng/ml, at 12.00 a.m.: 18.95 ng/ml, at 4.00 a.m.:18,24 ng/ml. Statistically significant differences between control group and RA patients were found at 4.00 p.m. (*p
Key words:
rheumatoid arthritis, prolactin, diurnal variation
Labels
Dermatology & STDs Paediatric rheumatology RheumatologyArticle was published in
Czech Rheumatology
2004 Issue 3
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