Gestagenic Depot Contraception
Depotní gestagenní kontracepce
Cíl studie:
Přehled poznatků o depotní gestagenní kontracepci.Typ studie: Přehledný článek.Název a sídlo pracoviště: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha.Závěr: Depotní gestagenní kontracepce zahrnuje systémy, založené na kontinuálním uvolňování malé dávky gestagenu do cirkulace. Účinnými látkami jsou depotní medroxyprogesteron acetát (DMPA) v injekční formě Depo-Provery a levorgestrel jako aktivní součást implantátu Norplant. Mechanismus účinku depotní gestagenní kontracepce je v asynchronní maturaci žlázek a stromatu endometria, která znemožňuje implantaci. Účinnost obou metod je velmi vysoká. Návrat plodnosti je po extrakci Norplantu okamžitý, po vysazení Depo-Provery trvá několik měsíců. Depotní gestagenní kontracepce má minimum kontraindikací, které jsou jen relativní a lze ji užít u žen s kontraindikacemi kombinované perorální kontracepce. Nejzávažnějším nežádoucím účinkem je ztráta cyklicity menstruačního krvácení.
Klíčová slova:
účinné látky, mechanismus účinku, návrat plodnosti, kontraindikace
Authors:
D. Koryntová 1; P. Čepický 1,2; J. Živný 1
Authors‘ workplace:
Gynekologicko-porodnická klinika VFN a 1. LF UK, Praha, přednosta prof. MUDr. J. Živný, DrSc. 2Levret, s. r. o., Praha, vedoucí MUDr. PhDr. P. Čepický, CSc.
1
Published in:
Ceska Gynekol 2001; (3): 202-207
Category:
Overview
Objective:
Summary of contraceptive implants and injectable contraceptives.Design: Review of the literature.Setting: Department of Gynaecology and Obstetrics, 1st Faculty of Medicine, Charles University, Prague.Results: Contraceptive implants and injectable contraceptives are systems based on continuous release of small dose of progestogen in the circulation. Active substances are depo-medroxyprogesterone acetate in the Depo-Provera injections and levonogestrel in Norplant implants. Mechanisms of action are: inhibition of ovulation, impermeability of cervical mucus and synchronisation of maturation of endometrial stroma and glands. Efficacy of both of the methods is very high. Recovery of fertility is immediately in after Norplant removal and in few months after discontinuation of Depo-Provera. Progesteron only contraception has only very few contraindications which are only relativ. It is possible to use her by the women with contraindications of combined oral contraception. The main side effect is altered menstrual bleeding pattern.
Key words:
active substances, mechanism of action, recovery of fertility, contraindications
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2001 Issue 3
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