Daprodustat: a new approach to the treatment of anemia in chronic kidney disease

Czech version

Authors: Viktória Paulusová; Pavel Ryšánek; Martin Šíma; Ondřej Slanař
Authors‘ workplace: Farmakologický ústav, 1. lékařská fakulta, Univerzita Karlova a Všeobecná fakultní nemocnice v Praze
Published in: Čes. slov. Farm., 2024; 73, 110-112
doi: https://doi.org/10.36290/csf.2024.013

Overview

Daprodustat, also known under the trade name DUVROQ, is a small molecule developed by GlaxoSmithKline, which has become a promising drug in the field of anemia treatment in patients with chronic kidney disease. Daprodustat belongs to a group of drugs called hypoxia-inducible factor prolyl hydroxylase inhibitors. These drugs interfere with the regulation of erythropoietin, which is a key factor in the production of red blood cells. This drug was approved in Japan in June 2020 and clinical studies with it are ongoing in several countries around the world, where they focus on evaluating the effectiveness and safety in various populations of patients with chronic kidney disease.

Keywords:

daprodustat – hypoxia-inducible factor prolyl hydroxylase inhibitors – chronic kidney disease.

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