Conformational Study of Drugs with Effect on I1-Imidazoline Receptors

České info

Konformačné štúdium liečiv účinkujúcich na I1-imidazolínové receptory

Uskutočnila sa konformačná analýza bázických štruktúr piatich agonistov I1-receptorov (klonidín,moxonidín,rilmenidín,fentolamín a fencyklidín)a jedného antagonistu I1-receptorov (idazoxan)metódou MM2.Štruktúra stabilných konformácií sa optimalizovala metódou AM1.Vizualizovalasa podobnosť stabilných konformácií jednotlivých látok.Ďalej sa vypočítala protónová afinitaa lipofilita,ktoré môžu výrazne vplývať na afinitu k receptoru a účinok látok.Je zrejmé,že všetkyštudované liečivá,až na fencyklidín,sú schopné zaberať rovnaký priestor a dôležitú úlohu pre afinituštudovaných liečiv k I1-receptorom môže mať nízka lipofilita (logP =1 až 2).

Klíčová slova:
I1-imidazolínové receptory –⁠ antihypertenzíva –⁠ konformačná analýza –⁠ klonidín –moxonidín –rilmenidín –⁠ fentolamín –fencyklidín

Authors: V. Garaj; M. Remko
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2002; , 196-199
Category:

Overview

Conformational analysis of five I1-receptor agonists in the neutral form (clonidine,moxonidine,rilmenidine,phentolamine,and phencyclidine)and one antagonist of I1-receptors (idazoxane)wascarried out by means of the MM2 method.Structures of stable conformations of individualcompounds were fully optimised.Degree of similarity of stable conformations was visualized.Theproton affinities and lipophilicities of title compounds were also computed.It is obvious that allstudied drugs except phencyclidine are able to occupy the same space.An important role for affinityof studied drugs towards I1-receptors can be played by their different hydrophobicity (logP =1 až 2).

Key words:
I1-Imidazoline receptors –⁠ antihypertensives –⁠ conformational analysis –⁠ clonidine–moxonidine –rilmenidine –⁠ phentolamine –phencyclidine

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Article was published in

Czech and Slovak Pharmacy

2002 Issue 4