Bilateral Ischemic Retinopathy and Optic Neuropathy as an Isolated Ophthalmic Clinical Entity in Altitude Sickness – a Case Report
Authors:
N. Jirásková 1; E. Rencová 1; O. Renc 2
; P. Rozsíval 1
Authors‘ workplace:
LF UK a FN Hradec Králové
Oční klinika
1; LF UK a FN Hradec Králové
Radiologická klinika
2
Published in:
Cesk Slov Neurol N 2011; 74/107(5): 575-578
Category:
Case Report
Overview
The authors relate a case of bilateral ischemic damage to the choroid, retina and optic nerve in a patient with sudden painless damage to vision that she suffered at the end of a month in Nepal which involved short trips to altitudes of around 5000 m. At initial ophthalmic examination she presented with asymmetrical oedema of the optic nerve discs, more pronounced in the left eye, with reduced visual acuity and lower altitudinal visual field defect. The results of tests and examinations were negative for infectious, auto-immune and demyelinating aetiology of the fundus. Treatment with corticosteroids and aceazolamid produced good results – resolution of ischemic and inflammatory changes in the fundus. In this case, a permanent deterioration of visual function in the left eye corresponding to subatrophy of the optic nerve head was observed, according to the literature a rare condition.
Key words:
altitude sickness – ischemic optic neuropathy – high-altitude retinopathy
Sources
1. Wiedman M, Tabin GC; High-altitude retinopathy and altitude illness. Ophthalmology 1999; 106(10): 1924–1927.
2. Morris DS, Sommer J, Donald MJ, Mc Cormick IJ, Bourne RR, Huang SS et al. The eye altitude. Adv Exp Med Biol 2006; 588 : 249–270.
3. Clarke C. Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia. Postgrad Med J 2006; 82(973): 748–752.
4. Bosch MM, Merz TM, Barthelmes D, Petrig BL, Truffer F, Bloch KE et al. New insights into ocular blood flow at very high altitudes. J Appl Physiol 2009; 106(2): 454–460.
5. Müllner-Eidenböck A, Rainer G, Strenn K, Zidek T. Hihg-altitude retinopathy and retinal vascular dysregulation. Eye 2000; 14(5): 724–729.
6. Rennie D, Morrisey J. Retinal changes in Himalayan climbers. Arch Ophthalmol 1975; 93(6): 395–400.
7. Bosch MM, Barthelmes D, Merz TM, Bloch KE, Turk AJ, Hefti U et al. High incidence of optic disc swelling at very high altitudes. Arch Ophthalmol 2008; 126(5): 644–650.
Labels
Paediatric neurology Neurosurgery NeurologyArticle was published in
Czech and Slovak Neurology and Neurosurgery
2011 Issue 5
- Hope Awakens with Early Diagnosis of Parkinson's Disease Based on Skin Odor
- Metamizole vs. Tramadol in Postoperative Analgesia
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Memantine in Dementia Therapy – Current Findings and Possible Future Applications
- Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
-
All articles in this issue
- Developmental Coordination Disorder – Developmental Dyspraxia
- Awake Resection of Adult Supratentorial Low-grade Gliomas Located within or Adjacent to Eloquent Areas
- Cognitive Evoked Potentials
- Early-Onset Hereditary Alzheimer’s Disease Caused by p.M139V Mutation in the PSEN1 Gene – a Case ReportAlzheimerova demence je nejčastější demence u pacientů ve starším věku. V některých rodinách může být geneticky podmíněna. Naše kazuistika ukazuje případ 43letého muže, v jehož rodině se vyskytlo dalších šest členů rodiny s manifestací demence ve věku 40–50 let. Genetickým vyšetřením byla u pacienta prokázána patogenní mutace c.415A>G (p.M139V) v exonu 5 genu PSEN1 v heterozygotním stavu. Stejná mutace byla zjištěna u demencí postiženého bratrance. V rodině tak byla potvrzena hereditární predispozice k časné formě Alzheimerovy demence s autozomálně dominantní dědičností na molekulární úrovni. Vývoj onemocnění byl u pacienta sledován po dobu osmi let. Postupně dochází k deterioraci kognitivních funkcí a vývoji atrofických změn mozku dle magnetické rezonance. Obdobné změny jsou pozorovány u jeho bratrance. Genetické vyšetřování v rodinách zasažených demencí může být do budoucna důležité především pro možnost včasné léčby pacientů v riziku.
- Bilateral Ischemic Retinopathy and Optic Neuropathy as an Isolated Ophthalmic Clinical Entity in Altitude Sickness – a Case Report
- Progressing Spasticity, Cognitive Deficit and Non-elicitable Cortical Motor Evoked Potentials as Signs of Probable Primary Lateral Sclerosis – a Case Report
- Quality of Life after Deep Brain Stimulation in Patients with Advanced Parkinson’s Disease
- The Prevention of Venous Thrombosis and Pulmonary Embolism in Neurosurgery
- Experience with a Burr-hole Craniostomy for Chronic Subdural Hematoma
- Cognitive Deficit in Patients with Clinical Isolated Syndrome and Multiple Sclerosis
- Aggregometry in Secondary Prevention of Stroke. Aspirin Resistance
- Eye Movement Examination in Neurological Practice
- Calcifying Pseudoneoplasms of the Neural Axis. Report of Three Cases
- Czech and Slovak Neurology and Neurosurgery
- Journal archive
- Current issue
- About the journal
Most read in this issue
- Developmental Coordination Disorder – Developmental Dyspraxia
- Cognitive Evoked Potentials
- Progressing Spasticity, Cognitive Deficit and Non-elicitable Cortical Motor Evoked Potentials as Signs of Probable Primary Lateral Sclerosis – a Case Report
- Experience with a Burr-hole Craniostomy for Chronic Subdural Hematoma