Radiation-Induced Meningiomas

Czech version

Authors: R. Jančálek ¹; Z. Novák ¹; J. Chrastina ¹; B. Slaná ²; V. Feitová ³
Authors‘ workplace: LF MU a FN u sv. Anny v Brně Neurochirurgická klinika ¹; LF MU a FN u sv. Anny v Brně I. patologicko-anatomický ústav ²; LF MU a FN u sv. Anny v Brně Klinika zobrazovacích metod ³
Published in: Cesk Slov Neurol N 2011; 74/107(2): 191-196
Category: Short Communication

Overview

Radiotherapy has recently become a standard procedure for the treatment not only of high-grade intracranial tumours but also of some of benign nature. Despite its therapeutic potential, radiotherapy can act as a trigger for carcinogenesis. Meningiomas are the most frequent intracranial tumours induced by radiotherapy because the radiosensitivity of meningeal tissue is high. Radiation-induced meningiomas differ from spontaneous meningiomas in their higher incidence in younger age groups. They are also more frequently multiple with histological abnormalities and a higher incidence of recurrence. First-choice therapy for radiation-induced meningiomas is surgical. Stereoradiosurgery appears to be the treatment of choice for progressive meningiomas in locations inaccessible to surgical approach. Three cases of radiation-induced meningiomas were found in a retrospective study of patients treated at the Department of Neurosurgery, St. Anne’s University Hospital, Brno. In conclusion, radiation-induced meningiomas form a specific group. Their specific features should be borne in mind in the course of oncology care.

Key words:
radiation-induced meningiomas –⁠ features –⁠ therapy

Sources

1. HQ, Higinbotham NL, Stewart FW, Coley BL. Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1998; 82(1): 8–34.

2. Breen P, Flickinger JC, Kondziolka D Martinez AJ. Radiotherapy for nonfunctional pituitary adenoma: analysis of long-term tumor control. J Neurosurg 1998; 89(6): 933–938.

3. Laws ER jr, Vance ML. Radiosurgery for pituitary tumors and craniopharyngiomas. Neurosurg Clin N Am 1999; 10(2): 327–336.

4. Cantini R, Giorgetti W, Valleriani AM, Burchianti M Amodeo C. Radiation-induced cerebral lesions in childhood. Childs Nerv Syst 1989; 5(3): 135–139.

5. Dweik A, Maheut-Lourmiere J, Lioret E, Jan M. Radiation-induced meningioma. Childs Nerv Syst 1995; 11(11): 661–663.

6. Sznajder L, Abrahams C, Parry DM, Gierlowski TC, Shore-Freedman E, Schneider AB. Multiple schwannomas and meningiomas associated with irradiation in childhood. Arch Intern Med 1996; 156(16): 1873–1878.

7. Sadetzki S, Flint-Richter P, Ben-Tal T, Nass D. Radiation-induced meningioma: a descriptive study of 253 cases. J Neurosurg 2002; 97(5): 1078–1082.

8. Rubinstein AB, Shalit MN, Cohen ML, Zandbank U Reichenthal E. Radiation-induced cerebral meningioma: a recognizable entity. J Neurosurg 1984; 61(5): 966–971.

9. Harrison MJ, Wolfe DE, Lau TS, Mitnick RJ Sachdev VP. Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature. J Neurosurg 1991; 75(4): 564–574.

10. D‘Ambrosio AL, Bruce JN. Treatment of meningioma: an update. Curr Neurol Neurosci Rep 2003; 3(3): 206–214.

11. Pollock BE, Stafford SL, Utter A, Giannini C, Schreiner SA. Stereotactic radiosurgery provides equivalent tumor control to Simpson Grade 1 resection for patients with small -⁠ to medium-size meningiomas. Int J Radiat Oncol Biol Phys 2003; 55(4): 1000–1005.

12. Liscák R, Simonová G, Vymazal J, Janousková L Vladyka V. Gamma knife radiosurgery of meningiomas in the cavernous sinus region. Acta Neurochir (Wien) 1999; 141(5): 473–480.