ACCOMPLISH study
Authors:
J. Špác
Published in:
Kardiol Rev Int Med 2008, 10(4): 153-155
Overview
In the ACCOMPLISH study, a high percentage of pati ents with hypertensi on and cardi ovascular or renal damage re ached blo od pressure target values with a therapy combining an ACE inhibitor and a calci um channel blocker (CBB), which reflected in a lower incidence of both fatal and non‑fatal cardi ovascular events. The results of the study support the use of combinati on ACE inhibitor and CBB therapy in initi al tre atment in high‑risk pati ents with hypertensi on.
Key words:
combinati on therapy of hypertensi on – ACE inhibitors – calci um channel blockers
Sources
1. Bangalore S, Kamalakkannan G, Parkar S et al. Fixed - Dose Combinati ons Improve Medicati on Compli ance: A Meta‑Analysis. The American Jo urnal of Medicine 2007; 120 : 713 – 719.
2. Kaplan NM. Low‑dose combinati on therapy: the rati onalizati on for an ACE inhibitor and a calci um channel blocker in higher risk pati ents. Am J Hypertens 2001; 14 : 8S – 11S.
3. Jamerson KA et al. ACCOMPLISH (Avo iding Cardi ovascular Events in Combinati on Therapy in Pati ents Living with Systolic Hypertensi on). Am J Hypertens 2003; 16 (part 2): 193A.
4. Jamerson KA on behalf of the ACCOMPLISH investigators. Avo iding cardi ovascular events in combinati on therapy in pati ents living with systolic hypertensi on. American College of Cardi ology Sci entific Sessi ons. March 31, 2008; Chicago, IL.
5. Bertrand M, Sever P. Synergistic effect of perindopril and calci um channel blockers in preventi on of cardi ac events and de ath in coronary artery dise ase pati ents – analysis from the EUROPA study. Clinical Tri al Update II. [http://www.escardi o.org/congresses/esc2008/congress – reports/Pages/3267 – 3268 – bertrand - sever.aspx].
Labels
Paediatric cardiology Internal medicine Cardiac surgery CardiologyArticle was published in
Cardiology Review
2008 Issue 4
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