Oral Premedication with Depot Morphine Formula
Perorální premedikace depotní formou morfinu
V retrospektivní studii bylo na souboru 250 pacientů hodnoceno užití retardovaného hydrochloridu morfinu (Vendal retard) v premedikaci předoperacemi páteře a periferních nervů. Současně byla sledována i jeho kombinace s jinými farmaky – nesteroidním antirevmatikem ketoprofenema benzodiazepiny. Byly posuzovány nežádoucí účinky retardovaného morfinu, nutnost užití atropinu nebo naloxonu, spotřeba opioidů během celkovéanestezie, stupeň účinnosti premedikace a pooperační analgezie. Ze studie vyplývá, že perorální premedikaci retardovaným hydrochloridem morfinuv dávce 10 mg a 20 mg v kombinaci s nesteroidním antirevnatikem ketoprofenem v dávce 100 mg a benzodiazepiny (zejména oxazepamem v dávce10 mg) lze doporučit nejen v uvedených, ale i v některých dalších vhodných indikacích.
Klíčová slova:
premedikace – retardovaný hydrochlorid morfinu – kombinace s NSAID – operace páteře a periferních nervů – pooperační analgezie
Authors:
V. Špatenková 1; J. Holub 2
Authors‘ workplace:
Neurocentrum Nemocnice Liberec, primář MUDr. Petr Suchomel
1
Published in:
Anest. intenziv. Med., , 2000, č. 4, s. 141-143
Category:
Overview
In a retrospective study we evaluated morphine hydrochloride (Vendal retard) in premedication for spinal surgery or peripheral nerve surgery. 250patients were enrolled. We also monitored its combination with other pharmacological agents – non-steroidal anti-inflammatory drug ketoprofen andbenzodiazepines. We evaluated adverse effects of depot morphine formula, the need for atropine or naloxone administration, opioid dose duringanesthesia, the effects of premedication and postoperative analgesia. Oral premedication with depot formula of morphine hydrochloride, 10 mg or20 mg, in combination with non-steroidal anti-inflammatory drug ketoprofen, 100 mg, and benzodiazepine (especially oxazepam 10 mg) could berecommended not only in above mentioned, but also in other feasible indications.
Key words:
premedication – morphine hydrochloride retard – combination with NSAID – spinal and peripheral nerve surgery – postoperative analgesia
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2000 Issue 4
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