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Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)


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Vyšlo v časopise: Emerging Function of Fat Mass and Obesity-Associated Protein (Fto). PLoS Genet 9(1): e32767. doi:10.1371/journal.pgen.1003223
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1003223

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Zdroje

1. FraylingTM, TimpsonNJ, WeedonMN, ZegginiE, FreathyRM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889–894.

2. ToddJA, WalkerNM, CooperJD, SmythDJ, DownesK, et al. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39: 857–864.

3. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661–678.

4. GerkenT, GirardCA, TungYC, WebbyCJ, SaudekV, et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318: 1469–1472.

5. HanZ, NiuT, ChangJ, LeiX, ZhaoM, et al. (2010) Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464: 1205–1209.

6. ChurchC, LeeS, BaggEA, McTaggartJS, DeaconR, et al. (2009) A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 5: e1000599 doi:10.1371/journal.pgen.1000599.

7. FischerJ, KochL, EmmerlingC, VierkottenJ, PetersT, et al. (2009) Inactivation of the Fto gene protects from obesity. Nature 458: 894–898.

8. GaoX, ShinYH, LiM, WangF, TongQ, et al. (2010) The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE 5: e14005 doi:10.1371/journal.pone.0014005.

9. ChurchC, MoirL, McMurrayF, GirardC, BanksGT, et al. (2010) Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 42: 1086–1092.

10. SpeakmanJR, RanceKA, JohnstoneAM (2008) Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 16: 1961–1965.

11. DoR, BaileySD, DesbiensK, BelisleA, MontpetitA, et al. (2008) Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57: 1147–1150.

12. HauptA, ThamerC, StaigerH, TschritterO, KirchhoffK, et al. (2009) Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 117: 194–197.

13. CecilJE, TavendaleR, WattP, HetheringtonMM, PalmerCN (2008) An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359: 2558–2566.

14. SpeakmanJR (2010) FTO effect on energy demand versus food intake. Nature 464: E1; discussion E2.

15. McMurrayFCC, LarderR, NicholsonG, WellsS, et al. (2013) Adult onset global loss of the Fto gene alters body composition and metabolism in the mouse. PLoS Genet 9: e1003166 doi:10.1371/journal.pgen.1003166.

16. Cheung MK, Gulati P, O'Rahilly S, Yeo GS (2012) FTO expression is regulated by availability of essential amino acids. Int J Obes (Lond). Epub ahead of print 22 May 2012. doi:10.1038/ijo.2012.77

17. ButlerAA, KozakLP (2010) A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 59: 323–329.

18. TschopMH, SpeakmanJR, ArchJR, AuwerxJ, BruningJC, et al. (2012) A guide to analysis of mouse energy metabolism. Nat Methods 9: 57–63.

19. KowalskaI, AdamskaA, MaleckiMT, Karczewska-KupczewskaM, NikolajukA, et al. (2012) Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 77: 120–125.

Štítky
Genetika Reprodukčná medicína

Článok vyšiel v časopise

PLOS Genetics


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