Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility


Autoři: Jeremy Ryan de Silva aff001;  Amirah Amir aff001;  Yee Ling Lau aff001;  Choo-Huck Ooi aff002;  Mun Yik Fong aff001
Působiště autorů: Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia aff001;  Sarawak State Health Department, Jalan Diplomatik, Off Jalan Bako, Kuching, Sarawak, Malaysia aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pone.0222681

Souhrn

The Duffy blood group plays a key role in Plasmodium knowlesi and Plasmodium vivax invasion into human erythrocytes. The geographical distribution of the Duffy alleles differs between regions with the FY*A allele having high frequencies in many Asian populations, the FY*B allele is found predominately in European populations and the FY*Bes allele found predominantly in African regions. A previous study in Peninsular Malaysia indicated high homogeneity of the dominant FY*A/FY*A genotype. However, the distribution of the Duffy genotypes in Malaysian Borneo is currently unknown. In the present study, the distribution of Duffy blood group genotypes and allelic frequencies among P. knowlesi infected patients as well as healthy individuals in Malaysian Borneo were determined. A total of 79 P. knowlesi patient blood samples and 76 healthy donor samples were genotyped using allele specific polymerase chain reaction (ASP-PCR). Subsequently a P. knowlesi invasion assay was carried out on FY*AB/ FY*A and FY*A/ FY*A Duffy genotype blood to investigate if either genotype conferred increased susceptibility to P. knowlesi invasion. Our results show almost equal distribution between the homozygous FY*A/FY*A and heterozygous FY*A/FY*B genotypes. This is in stark contrast to the Duffy distribution in Peninsular Malaysia and the surrounding Southeast Asian region which is dominantly FY*A/FY*A. The mean percent invasion of FY*A/FY*A and FY*A/FY*B blood was not significantly different indicating that neither blood group confers increased susceptibility to P. knowlesi invasion.

Klíčová slova:

Biology and life sciences – Biogeography – Evolutionary biology – Genetics – Population genetics – Phylogeography – Heredity – Genetic mapping – Variant genotypes – Population biology – Cell biology – Cellular types – Animal cells – Blood cells – Red blood cells – Anatomy – Body fluids – Blood – Blood groups – Physiology – Parasitology – Parasite groups – Apicomplexa – Plasmodium – Molecular biology – Molecular biology techniques – Artificial gene amplification and extension – Polymerase chain reaction – Ecology and environmental sciences – Earth sciences – Geography – People and places – Geographical locations – Asia – Borneo – Malaysia – Medicine and health sciences – Research and analysis methods


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